Author: Jahmal Ennis | Computational and Integrative BiologyAbstract: The success of the Martini force field is largely due to its ability toreproduce experimental phenomena, its extensive library of biologicalmolecules, and the abundance of tools available to further developmodels of small molecules. However, many inorganic materialscannot be investigated in Martini because they have no directcorrespondence to… continue reading
Author: Aleece Siner | Computational and Integrative BiologyAbstract: Organisms adapt to seasonal changes driven by Earth’s rotation around the sun, with photoperiod influencing their biological rhythms. While photoperiodism has been more extensively studied in plants, the mechanisms underlying seasonal responses in fungi remain largely unexplored. This study explores novel mechanisms and identifies genetic components involved… continue reading
Author: L. Caden Comsa | Computational and Integrative BiologyAbstract: The past century has been marked by the increasing effects of anthropogenic change, causing multiple threats to global biodiversity such as via reductions in many species’ population sizes and genetic health. As populations are driven to ever smaller sizes, the accumulation of genetic defects due to… continue reading
Author: Rahmah Mohammed Imthiyas | Computational and Integrative BiologyAbstract: Solid-state nanopores provide a powerful platform for single-molecule sensing by detecting transient disruptions in ionic current as molecules translocate through nanoscale pores. In this study, we investigate the translocation behavior of a single-stranded DNA probe in a solid-state nanopore system and evaluate how key experimental parameters… continue reading
Author: Lindsey Riggs | Computational and Integrative BiologyAbstract: Intrinsically disordered proteins (IDPs) sample a broad distribution of conformational states rather than adopting a single conformation, representing the conformational ensemble. The lack of a defined structure makes it challenging to interpret how a missense mutation in the sequence of an IDP affects its ensemble. Current methods… continue reading
Author: Zion Harris | Computational and Integrative BiologyAbstract: Background: Human papillomavirus (HPV) is a leading cause of cervical and other anogenital cancers in the United States, with persistent disparities in incidence and mortality across socioeconomic, racial, and geographic groups. Unequal access to vaccination, screening, and preventive care contributes to sustained HPV-related cancer burden, particularly in… continue reading
